Spring 2007
Issue 49

Network Prepares for Renewal

The Network’s Renewal Team has completed the first draft of its Second-Round of NCE Funding application, and presented it before an expert "Red Team" panel on Thursday, May 10th in Ottawa. The review was very worthwhile and generated a lot of useful feedback to fine-tune the final Renewal Submission, which is due on July 10th.

The main element of the proposal is the research plan. In response to its call for letters of intent earlier this year, the Network received 12 applications which were reviewed by the SCN's International Scientific Advisory Board (SAB) in February along with the strategic plans for the 14 existing core projects. Based on the SAB recommendations, the Research Management Committee identified 14 projects for inclusion in the application.

If the Network is successful in securing a second round of NCE funding an open call for full proposals will be issued in
January 2008.

Program I – Cellular Therapeutics

  1. Retinal Stem Cells—Biology and Therapeutic Applications
  2. Stem Cell-based Gene Therapy for Hemophilia A
  3. Stem Cells for the Treatment of Parkinson’s Disease
  4. Cell therapy for muscular disease
  5. Pilot Transplantation Studies using Stem Cells and Progenitors
  6. Stem Cells to Treat Spinal Cord Injury
  7. Canadian Cord Blood Stem Cell Initiative

Program II – Pharmacological Applications   

  1. Cancer Stem Cell Genomics and Therapeutics
  2. High content, HTS for molecules that promote beta cell formation
  3. Endogenous Repair of CNS Injury

Program III – Tools, Reagents & Devices       

  1. Long Term Imaging And Cell Tracking For Stem Cell Lineage Analysis
  2. Development of Technologies for the Derivation, Propagation and Differentiation of hESC

Program IV – Public Policy     

  1. Towards the Clinic?: Ethical, Legal & Social Issues Relevant to Emerging Stem Cell Therapies
  2. Assessment, Allocation and Access: Stem Cells and Health Systems

New Funding

At the most recent meeting of the SCN Board, three new grants were made following the recommendation of the RMC:

  1. Cancer Stem Cell Project ($152,500)
  2. Gene Expression Signatures and Clinical stem cell grants ($50,000)
  3. Catalyzing Umbilical Cord Blood Research in Canada (Up to $50,000 contingent on budget)

SCN Co-op Award

Deadline: June 1, 2007

The award provides funds towards a salary for a co-op student to work on a research project with clear relevance to stem cells.

Applicants must be enrolled in a co-operative program at a Canadian university and working towards their undergraduate degree.

Visit the SCN website for more information.

Courses & Workshops

Hands-on Workshop for New Cell Culture Users

Deadline: May 22, 2007

As part of the ongoing partnership between SCN and the Training Program in Regenerative Medicine (TPRM), we are pleased to announce the upcoming Corning Life Sciences Cell Culture Workshop on May 30-31, 2007.  This 2-day, hands-on workshop will take place at the Toronto’s Industrial BioDevelopment Laboratory (IBDL;), and is aimed at trainees who are new to cell culture.  Participants will learn aseptic techniques, media preparation, cell seeding on different surfaces, freezing, thawing, assessing viability, suspension and adherent culture.  A workshop agenda can be found online.

There is one space being held for an SCN trainee to attend this workshop.  SCN will cover the cost of travel, accommodations and meals for the successful SCN applicant (for more information on SCN’s contribution, contact Tia Moffat).

For more information on this workshop, and to register, contact Andre Siegel at the IBDL by May 22, 2007.

SCN Thematic Workshop for Bioengineering Students

Deadline for abstract submission to the CSChE conference is June 4, 2007.

Jamie Piret is organizing a SCN bioengineering workshop this October at the 57th annual Canadian Chemical Engineering Conference in Edmonton, Alberta.  In past years, this workshop has augmented CSChE participation by SCN bioengineers, yielding remarkable stem cell sessions as a conference highlight.  The main purpose of the workshop is to allow networking between bioengineers, with SCN PIs introducing their research progress for the past year, followed by more detailed SCN trainee presentations and general group discussions.  The workshop will include a networking dinner.

SCN trainees are encouraged to submit an abstract and to participate in the SCN bioengineering workshop at the CSChE conference. 

Please contact Jamie Piret.

Microarray Analysis Course

Available Online

An online course series on the analysis of Affymetrix microarrays. is now availble through the OHRI website.

This series was produced for the Stem Cell Network by Dr. Miguel Andrade's Bioinformatics Lab at the Ottawa Health Research Institute. The course consists of a series of units, each of which has an online lecture, a set of references and recommended readings, and an assignment.

This online course is available on the Ontario Genomics Innovation Centre website.

Please contact us at ogicinfo@ohri.ca is you have any questions, comments or suggestions.

Transitional Research Grant

Following the review of 6 proposals, the Training Committee awarded Afshin Raouf of Connie Eaves' Lab with a Transitional Research Grant .

This grant offers Afshin the opportunity to develop his research career by providing him with financial support to manage a research project while under the supervision of his SCN principal investigator.

Co-op awards

Following the review of 11 applications, the Training committee awarded 5 co-op awards as follow:

Andrew Giacomelli (John Hassell’s lab)
Michael Li (Connie Eaves’ lab)
Andra Nica (Peter Zandstra’s lab)
Thushaanthini Thavaratnam (Edna Einsiedel’s group)
Sarah Vollett (Keith Humphries’ lab)

Other Awards

SCN trainee Jaymi Cormier from Derrick Rancourt’s lab (and former student of Michael Kallos) has been awarded the Canada Graduate Scholarship

The award of $105,000 over the next 36 months, is the top graduate studentship awarded by NSERC.

Network conducts online survey on Research Leadership and Management.

Dr Rancourt and the SCN Training Committee are exploring the needs and interest in
Research Leadership and Management training within our community.  Starting this week we will be conducting a survey to identify the awareness, competency and training needs of network members in such diverse areas as strategic planning, external relations, project management and professional development.

The results of this survey will assist the Training Committee in developing a leadership training curriculum, which could be in turn be used as a model for other networks in Canada and internationally.

If you have not received an invitation to take part in the survey, and would like to do so, please email Lori Barron.

A Book Review

by Gareth Palidwor 

Alternative Careers in Science: Leaving the Ivory Tower
Second Edition, Edited by Cynthia Robbins-Roth

$34.95, available at Chapters  

At the graduate level, life sciences education in Canada emphasizes training for a career in research, usually to the exclusion of other options. This is an unfortunate shortfall as most post-graduate careers don't lead directly or exclusively to research. According to Statistics Canada, in the 2003-2004 academic year, approximately 750 students graduated with PhDs in life sciences. It's certain that 750 permanent life sciences research positions did not become available in Canada that year or in any year since. Most of these graduates will not end up as principal investigators in research institutes or as university professors. Luckily there is a rich and challenging set of jobs available in industry and government organizations that support, produce and regulate research.

"Alternative Careers in Science: Leaving the Ivory Tower" is a book about these positions. It describes non academic track careers for people with graduate degrees emphasizing on life sciences and medical research positions. 23 different contributors from a broad range of disciplines outline their jobs and their often unique career paths. The chapters are each 10-20 pages long, focusing on a specific career and written by a contributor with notable experience in that area. The style and format of the sections are a bit uneven; some are chatty, humorous and filled with personal anecdotes, while listing a bland and objective job summary.  Most articles cover a common checklist of topics including pay scales, required skills and experience, and what an average day or week is like on the job. The jobs are grouped into general categories such as Science Careers in Government, The Corporate World and The Financial World allowing readers to easily find jobs in broader areas of interest.

It would be impossible to cover all science careers in a single book, but the scope of the book is impressive, from Military Research Program Manager to Technical Writer and everything in between. Some careers, such as Science Based Investment Advising were new and surprising to me. Though the book is advertised as being for science graduate students in general, it is biased towards life sciences and medical research careers, likely because this is the editor's background. Most of the contributors have PhDs and many have post-doctoral experience. Unfortunately it isn't often clear whether an MSc would be sufficient for a given position. The book was written for the US market, primarily by American contributors, so not all information is necessarily applicable to Canada. Salaries tend to be somewhat lower in Canada, and the government positions discussed may not have a direct equivalents in the Canadian federal government.

Overall the book is a worthwhile read for anyone that has a graduate degree, or is completing one. While the individual job descriptions are interesting, the most valuable aspect of the book is that it shows the incredible number of career options a life sciences graduate degree makes available to you.

TERMIS North America 2007 Conference and Exposition
2007-06-13 to 2007-06-16
Westin Harbour Castle Toronto, Ontario Canada
Learn More

5th ISSCR Annual Meeting
2007-06-17 to 2007-06-20
Cairns Convention Centre Cairns, Queensland, Australia
Learn More

Honing Your Leadership Skills through Teamwork

Derrick E. Rancourt

Academic leadership is largely judged by performance at the forefront of scientific or technological knowledge.  Its measure is publication in high impact journals, participation in international symposia, etc.  Hence, graduate students and postdocs are encouraged to work hard at the bench in order to accumulate high impact papers.  Unfortunately, this type of ambition forsakes the more conventional definition of leadership: “the art of influencing and directing people in such a way that will win their confidence, respect and loyal cooperation in achieving common objectives.”[1]  Astonishingly, many academics believe leadership is naturally bestowed upon an international authority.  Although this has never been true, these cultural assumptions are finally being tested as the research world embraces multi-disciplinary, multi-stakeholder modes of research[2]. Promoters of the “mode 2 research” concept suggest that research is more effective when conducted synergistically in multidisciplinary teams.

            World governments now invest in the mode 2 concept, so modern research has had to evolve beyond the single investigator model.  Today, principal investigators contend with multiple institutions, multiple research stakeholders, complex organizational structures (networks, centres, and teams,) and increased pressure for knowledge transfer and accountability.  Similarly, values surrounding leadership are evolving within this new reality.  Although caliber of research publications is still respected by other disciplines and stakeholders, the ability to develop and orchestrate wildly different resources towards a common goal defines the mode 2 leader.

            Often, this leadership ability challenges many scientists who are trained only with scientific and technical skills.  It is ironic that their success is now predicated upon their ability to lead teams when they have been encouraged to remain isolated and bench-focused throughout their training.  A mid-career scientist must juggle many tasks, including research, teaching, committee work, grants, papers, lectures, reviews, networking, etc.  This mid-level academic scientist moves from project to project adding momentum as they pass, much like a plate spinner at the circus. Unfortunately, the scientist in’t spinning plates, but people. These people include employees, trainees, colleagues, collaborators and potential collaborators. They all invest in and feed off this person.  Combine current pressures with little leadership and management training, it is no wonder many scientists retreat to small labs with little funding, forsaking their duties as teacher, mentor and promoter of innovation.

            Similar pressures exist in industry.  The desire for increased efficiency has driven the trend of “flattening” as the business world becomes increasingly competitive.  In this anti-pyramidical configuration, fewer layers of bureaucracy exist, leaving an integrated management and workers to form teams.  It is believed that flattening results in employees who are empowered, happier and more productive.  However, skeptics believe as Orwell suggests: “All are equal, but some are more equal” in a world of organizational equals[3].  In a world of flatter organizations and outsourcing, employees are measuring their importance by their project stature and are becoming more focused in their own skill development and portability, rather than the success of the organization.

            In classical corporate structure, scientists worked individually or in small scientific teams.  Their training made them well suited for this task until they were promoted to a management position, where they would often behave erratically based upon their limited leadership training[4]. In a flattening world, companies have moved to an organizational structure based upon product-focused multidisciplinary teams.  Many scientists find themselves developing products not with scientists but rather experts in marketing and finance.  They may even interact with customers, because customers are now brought into the product development cycle earlier. Accordingly, scientists often experience problems with communication, culture and leadership.

Industry leaders recognize that teamwork helps to train new leaders, so teamwork is a critical skill in new recruits.  Recruiters will probe teamwork experience with questions that include how you resolved roadblocks or conflicts within a team.  Your answers forge a picture of emerging leadership skills. Your abilities are important to the recruiter, because leadership is no longer concentrated at the top; it is now distributed, such that individuals lead different activities toward a common set of goals.  Some activities may be technical in nature, so the roles may depend upon technical expertise.  However, others could relate to team dynamics (facilitator, recorder, organizer, prodder, supporter, etc).  Each role is important, forming a part of a team, which works synergistically. If you fail to fill the needs of the team’s leadership vacancy, you will not get the job. 

Questions about teamwork allow recruiters to investigate other skills.  Modern organizations rely upon effective communication and goal orientation for their success.  An employee who is a skilled communicator, and who can cooperate and work efficiently in diverse environments will succeed in today’s fast paced corporate world.  Industry thrives on “mission critical” projects; these are high risk projects, which can catapult a company to the forefront of its competitors.  Companies are only interested in individuals who recognize the need for working synergistically towards a goal.

Lawrence Chambers argues, in Effective Communication Skills for Scientific and Technical Professionals communication is the single most important skill that researchers should learn before joining a company.  Without communication skills a new employee will be unable to establish relationships, which form the basis for trust, and synergy within the team.  Communication between disciplines further increases the challenge when working in multidisciplinary teams.  Hence, scientists must lose their field-specific jargon and simplify their concepts.  Furthermore, they must strive to fully understand the other team members’ contributions.  The trust arising from effective communication skills allows everyone the opportunity to air concerns or seek help.  It also fosters understanding and appreciation for problems other members face.  Finally, one the most difficult of leadership skills, negotiation, can only be learned through effective team communication.

Filling successful leadership roles within a team depends upon your personality.  Myers Briggs indicators are one measure of personality. Myers Briggs breaks down personality into four spectra. Extroverts think out loud and are great explainers, but can be overwhelming.  In contrast, Introverts concentrate well, but need time to think and they are often silent.  Intuitive people visualize the big picture, seeing all connections in everything; intuitive people are great planners but poor executors.  However, sensors are great executors, but often miss the importance of the big picture.  Thinkers understand how things work, while Feelers know why something matters.  Judgers make decisions quickly, are good at schedules, and completion, but may overlook vital issues.  Perceivers on the other hand, are slow to judge, always wanting more information and rarely acting.  Individuals with differing personality types bring different perspectives to a team.  Having a balance of personalities and understanding how others on a team view the world, helps teams to synergize. 

Personality traits often define what roles people naturally fall into, but they should not restrict individuals from filling more challenging roles.  Team building experts suggest team members must understand and communicate their personality “strengths and weakness” to other team members.  This helps define roles the team members would be comfortable in.  However, people must learn various leadership roles within teams.  It is important to discuss roles alongside the individuals’ expectations.  For example, a well-organized person doesn’t always want to organize things for the team. Indeed, personality traits can be modified.  Introverts, for example, may wish to facilitate to help them become more extroverted.

Understanding and communicating individual strengths and weaknesses can be expanded to develop a picture of the whole team’s strengths and weaknesses.  Knowing where a team is strong or where they need support is also an important part of strategic planning.  During strategic planning, teams use SWOT (strengths, weaknesses, opportunities and threats) analysis to examine operational, situational and competitive positions.  Teams look at both internal and external assessments to determine where they lie upon a SWOT matrix.  SWOT analysis guides future directions and planning for the team by identifying weaknesses and threats, which must be protected against, while strengths and opportunities may be exploited.

It is through teamwork, that the organization can develop a vision. Using SWOT analysis combined with team members’ values and expectations, the team develops a vision statement. The vision statement must resonate with team members to inspire their commitment, innovation and courage. From there the team begins to set goals. Goals must be SMART: specific, measurable, attainable, realistic and time-bound.  Furthermore, each goal must be championed and have an action plan, which defines who, what, where, when and how.  Finally, teams must review their goals regularly, which allow them to reward successes and “manage” productivity gaps.

As research trainees, there is no better time to “experiment” with teamwork and leadership skills. Being a part of a NCE provides you with a unique opportunity to work in multidisciplinary, multi-institutional teams.  The training committee is interested in supporting trainees form teams around their initiatives.  Take initiative.  Your leadership skills must be honed to ensure your success in the new research community, so find a way to train as a leader, not just a scientist.

Derrick E. Rancourt is the Director of the University of Calgary’s Master of Biomedical Technology, a one year course based MSc that integrates life science and business.  Elements of this paper were presented at an experimental trainee leadership workshop held in conjunction with the hESC project.



[1] http://www.legacee.com/Info/Leadership/Definitions.html

[2] Gibbons et al. (1994) The New Production of Knowledge: The Dynamics of Science and Research in Contemporary Societies (Sage, London).

[3] http://ezinearticles.com/?Working-in-FLAT-Organizations:-An-Idiots-Guide&id=124671

[4] Chambers (2001) Effective Communication Skills for Scientific and Technical Professionals.

Former SCN trainee, Zubin Master publishes article in the Journal of Medical Ethics.

Former SCN trainee has recently published an article in the Journal of Medical Ethics. The paper arose from the SCN Parkinson's Disease Project, lead by Dr. Ivar Mendez.

The paper entitled “Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson’s disease” attempts to assess the potential benefits and risks of stem cell transplantation for clinical research. An examination of the ethical requirements for the transplantation of stem cells for Parkinson’s diseases is timely because there is no known effective therapy and several years of clinical experience with neural transplantation for Parkinson’s disease exists.

Through examination of the clinical literature on the transplantation of fetal tissue in subjects with Parkinson’s disease and the biomedical literature on the transplantation of stem cells in various animal models, the authors determine a probable set of benefits and risks to research subjects and to society. This information is crucial for research ethics boards (in Canada) and institutional review boards (in the US) in order to ensure that risks in stem cell translational studies are minimized which is perhaps one of the most important criteria for research ethics review. The paper then discusses how the potential risks we determined can be minimized to ensure a favorable harm-benefit ratio such that the trial offers participants involved in clinical research a reasonable choice.

The article is available for download here.

Visit the Journal of Medical Ethics online at: http://jme.bmj.com/

Executive Committee Meeting
Teleconference
May 22, 2007

Research Management Committee Meeting
Teleconference
May 23, 2007

Board of Directors Meeting
Face-to-Face
June 4, 2007

Policy Development Committee Meeting
Teleconference
June 7, 2007

Audit and Finance Committee Meeting
TBD
June 2007

For questions on Network Meetings, please contact Lee Freeman

Do you have a story idea for CELLlines?
Have you been featured in the media?
Want to post a job ad?

Contact Lori Barron at
lori@stemcellnetwork.ca